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TAMOXIFEN INHIBITION OF AN in vitro OESTRADIOL‐INDUCED SURFACE COAT CHANGE ON MOUSE BLASTOCYSTS
Author(s) -
BLOXHAM P.A.,
PUGH D.M.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07529.x
Subject(s) - coat , tamoxifen , in vitro , chemistry , andrology , biology , pharmacology , endocrinology , medicine , biochemistry , paleontology , cancer , breast cancer
1 Eighty‐nine hour post‐coitus mouse blastocysts cultured in the presence of oestradiol‐17β underwent a histochemically detectable surface coat change. 2 Tamoxifen was found to inhibit this in vitro ‐induced change. The role of Tamoxifen as an inhibitor of implantation is discussed.