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THE EFFECTS OF METIAMIDE ON CELL‐MEDIATED IMMUNE REACTIONS IN THE GUINEA‐PIG
Author(s) -
DALE M. MAUREEN
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07520.x
Subject(s) - metiamide , sensitization , guinea pig , immune system , delayed hypersensitivity , cell mediated immunity , immunology , antagonist , pharmacology , immunity , chemistry , receptor , medicine , biochemistry , histamine h2 receptor
1 The effects of the H 2 ‐receptor antagonist, metiamide, on two types of cell‐mediated immune response in vivo was investigated in the guinea‐pig, in a test of the hypothesis that H 2 ‐receptor antagonists would result in ‘runaway’ unregulated hypersensitivity reactions. 2 Metiamide in doses of 5 mg‐125 mg/kg given by 6‐hourly injection during sensitization and challenge did not modify the delayed hypersensitivity reaction to tuberculin. 3 Metiamide in doses of 25‐125 mg/kg given by injection, 6‐hourly throughout sensitization to dinitrofluorobenzene (DNFB) and subsequent challenge six days later, did not modify the contact sensitivity reaction to DNFB. 4 It is concluded that metiamide, given during these cell‐mediated immune reactions in the guinea‐pig, does not enhance cell‐mediated hypersensitivity responses.