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SOME OBSERVATIONS ON THE ANORECTIC ACTIVITY OF PROSTAGLANDIN F 2α
Author(s) -
DOGGETT N.S.,
JAWAHARLAL K.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07516.x
Subject(s) - anorectic , prostaglandin f2alpha , anorexia , medicine , endocrinology , ingestion , chemistry , food intake , prostaglandin
1 Intracerebroventricular injection of prostanglandin F 2α (10‐40 μg) decreases food intake in a dose‐dependent manner in rats trained to consume their daily total food intake in a 2 h period. 2 This anorexia is also observed in satiated rats, which had ad libitum access to food. 3 The anorectic activity of prostaglandin F 2α is not modified by changes in the internal environment of the body after food intake, such as increased blood glucose and insulin levels and decreased fatty acid levels, or by the presence or absence of food in the stomach, as is evident from the anorectic activity of prostaglandin F 2α in partially satiated rats. 4 The anorexia is not due to pain or irritative properties of prostaglandin F 2α since induction of comparable pain with 3% acetic acid does not affect food intake in rats deprived of food for 22 hours. 5 Anorectic doses of prostaglandin F 2α when injected intraperitoneally cause hypothermia. 6 The results suggest that the inhibitory activity of prostaglandin F 2α on food intake is at both peripheral and central sites. 7 Prostaglandin F 2α ‐induced anorexia is associated with the behavioural tranquillization that is seen after the ingestion of food.