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COMPARISON OF THE EFFECTS OF CAFFEINE AND A 2‐ALKYL‐1,2,3‐BENZOTRIAZINIUM IODIDE ON FROG RECTUS ABDOMINIS
Author(s) -
MUIR C.K.,
SCOTT N.C.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07511.x
Subject(s) - caffeine , iodide , alkyl , rectus abdominis muscle , anatomy , chemistry , biology , endocrinology , organic chemistry
1 The mode of action of 2‐ n ‐propyl‐4‐ p ‐tolylamino‐1,2,3‐benzotriazinium iodide (TnPBI), which induced contractures of frog rectus abdominis muscle, was investigated. 2 TnPBI caused contractures of frog rectus abdominis when the muscle had been depolarized with potassium chloride. 3 Experiments with TnPBI and caffeine in calcium‐free Ringer suggested that both compounds produce contractures by releasing intracellular bound calcium. 4 It is suggested that at least two calcium stores are involved, one of which is sensitive to caffeine while both are sensitive to TnPBI.