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EFFECTS OF DIBUTYRYL CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE AND THEOPHYLLINE ON THE BULLFROG SYMPATHETIC GANGLION CELLS
Author(s) -
AKASU T.,
KOKETSU K.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07504.x
Subject(s) - bullfrog , theophylline , sympathetic ganglion , medicine , endocrinology , adenosine , ganglion , inhibitory postsynaptic potential , chemistry , cyclic adenosine monophosphate , biology , neuroscience , receptor
1 Effects of dibutyryl cyclic adenosine 3′,5′‐monophosphate (dibutyryl cyclic AMP) and theophylline on bullfrog sympathetic ganglion cells were examined in order to test the hypothesis that cyclic AMP is essential for the generation of slow inhibitory postsynaptic potentials (i.p.s.ps) in these cells. 2 In the absence or presence of theophylline, dibutyryl cyclic AMP did not hyperpolarize but rather tended to depolarize ganglia that were hyperpolarized by adrenaline. 3 Theophylline augmented neither the P‐potential (slow i.p.s.p.) nor adrenaline‐induced hyperpolarization. 4 Thus, cyclic AMP does not seem to be essential for the generation of the slow i.p.s.p., at least in amphibian sympathetic ganglion cells.