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THE EFFECTS OF BRADYKININ AND PROSTAGLANDIN E 1 ON RAT CUTANEOUS AFFERENT NERVE ACTIVITY
Author(s) -
CHAHL LORIS A.,
IGGO A.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07498.x
Subject(s) - bradykinin , prostaglandin , prostaglandin e1 , prostaglandin e , chemistry , endocrinology , prostaglandin e2 , afferent , prostaglandin antagonist , medicine , anesthesia , receptor
1 The activity produced by intra‐arterial bradykinin and prostaglandin E 1 was investigated in multifibre strands dissected from the saphenous nerves of anaesthetized rats. 2 Bradykinin (0.5‐10 μg) alone produced little activity in nerve strands but produced considerable activity following a 10 min infusion, but not a single injection, of prostaglandin E 1 (5‐100 ng). 3 Prostaglandin E 1 alone produced a few large height spikes but following several injections of bradykinin smaller height spikes were also produced by prostaglandin E 1 . 4 It was concluded that the presence of a low concentration of prostaglandin E 1 is required for bradykinin to manifest its action and that bradykinin and prostaglandin E 1 are mutually potentiating in their effects on afferent nerve terminals.