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MODIFICATION OF CARDIOVASCULAR RESPONSES TO HISTAMINE BY DITHIOTHREITOL
Author(s) -
CARROLL P.R.,
GLOVER W.E.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07497.x
Subject(s) - metiamide , mepyramine , histamine , dithiothreitol , pyrilamine , chemistry , medicine , vasodilation , endocrinology , pharmacology , histamine receptor , histamine h2 receptor , receptor , biochemistry , antagonist , enzyme
1 Histamine produced dose‐dependent contractile responses on both isolated perfused ear arteries and aortic strips of the rabbit. These responses were blocked by mepyramine and potentiated by both metiamide and dithiothreitol. 2 In the presence of maximum potentiation by metiamide, dithiothreitol still potentiated the contractile response to histamine of both preparations. 3 In the presence of mepyramine, histamine produced dose‐dependent reductions in the contractile response to noradrenaline. This vasodilator action of histamine was abolished by metiamide but was unaffected by dithiothreitol. 4 The vasodilator action of histamine on the human isolated perfused temporal artery and the positive inotropic effect of histamine on the isolated spontaneously beating atria of the rabbit were blocked by metiamide but unaffected by dithiothreitol. 5 It is concluded that the rabbit aorta, like the ear artery, contains both H 1 and H 2 histamine receptors and that dithiothreitol potentiates cardiovascular responses mediated by H 1 ‐receptors but not by H 2 ‐receptors.