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VASOCONSTRICTOR RESPONSE TO ARACHIDONIC ACID IN THE ISOLATED HIND LIMB OF THE DOG
Author(s) -
FITZPATRICK T.M.,
JOHNSON M.,
KOT P.A.,
RAMWELL P.W.,
ROSE J.C.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07489.x
Subject(s) - hindlimb , arachidonic acid , anatomy , neuroscience , biology , chemistry , medicine , biochemistry , enzyme
1 Arachidonic acid (AA) (25‐200 μg/kg) produced a dose‐related increase in perfusion pressure in dog isolated hind limbs perfused with either blood or a platelet‐free perfusate. 2 Prostaglandin E 2 produced vasodilatation while prostaglandin produced no vascular change at these administered doses. 3 Phentolamine did not alter the arachidonic acid response, eliminating possible α‐adrenoceptor mediation. 4 Aspirin and indomethacin blocked the vasoconstrictor response to AA. 5 This study indicates that a vasoactive intermediate in prostaglandin synthesis can be elaborated in the absence of platelets.