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VASCULAR REACTIVITY OF PERFUSED VASCULAR BED IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS
Author(s) -
BHATTACHARYA B.K.,
DADKAR N.K.,
DOHADWALLA A.N.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb07485.x
Subject(s) - medicine , endocrinology , blood pressure , mesenteric arteries , spontaneously hypertensive rat , angiotensin ii , blood vessel , artery , norepinephrine , chemistry , dopamine
1 Hypertensive and normotensive rats of the same age group were isolated from an inbred colony of spontaneously hypertensive rats. 2 The perfused hindquarter and mesenteric artery preparations obtained from hypertensive and normotensive rats exhibited an increased reactivity to noradrenaline (NA) and angiotensin II. 3 Dose‐response curves to NA obtained from hypertensive and normotensive rats exhibited a steeper slope and higher maximum than those from control rats. 4 These findings suggest that increased vascular reactivity of blood vessels is independent of the development or maintenance of elevated blood pressure.