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THE EFFECT OF NON‐STEROIDAL ANTI‐INFLAMMATORY DRUGS ON ADENOSINE TRIPHOSPHATE CONTENT AND HISTAMINE RELEASE FROM RAT PERITONEAL CELL SUSPENSIONS RICH IN MAST CELLS
Author(s) -
CHAMPION G.D.,
DAY R.O.,
RAY J.E.,
WADE D.N.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb06973.x
Subject(s) - histamine , adenosine triphosphate , in vitro , pharmacology , adenosine , chemistry , mast cell , compound 48/80 , mechanism of action , medicine , biochemistry , immunology , receptor , degranulation
1 Non‐steroidal anti‐inflammatory drugs (NSAID) suppressed compound 48/80‐induced histamine release from rat peritoneal cells in vitro in a dose‐dependent manner. 2 NSAID suppressed the adenosine triphosphate (ATP) content of rat peritoneal cells in vitro and this correlated strongly with the suppression of compound 48/80‐induced histamine release. 3 The correlation demonstrated suggests that the mechanism of action of NSAID in the rat peritoneal cells is via depletion of cellular ATP.