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THE β‐ADRENOCEPTOR OF THE HUMAN LYMPHOCYTE AND HUMAN LUNG PARENCHYMA
Author(s) -
CONOLLY M.E.,
GREENACRE J.K.
Publication year - 1977
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1977.tb06971.x
Subject(s) - practolol , propranolol , isoprenaline , endocrinology , medicine , salbutamol , adrenergic receptor , receptor , cyclic adenosine monophosphate , lymphocyte , pharmacology , chemistry , asthma , stimulation
1 The response of the β‐adrenoceptors of human lymphocytes to selective agonists and antagonists has been studied quantitatively by measuring changes in cyclic adenosine‐3′,5′‐monophosphate (cyclic AMP) levels. 2 The receptor was activated by isoprenaline and by salbutamol, and blocked by propranolol but not by practolol. A similar pattern of response was obtained with fragments of human lung tissue. 3 The mean value for pA 2 for propranolol was 8.34 and for practolol was 3.95. 4 These findings indicate that the lymphocyte β‐adrenoceptor is a β 2 ‐receptor and support the validity of using lymphocytes to study β‐adrenoceptor function in bronchial asthma. It may also be of use in the evaluation of selective β 2 ‐blocking drugs in man.