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RENAL FUNCTION AND RENAL VENOUS PROSTAGLANDIN CONCENTRATIONS DURING DIFFERENT STAGES OF EXPERIMENTAL RENAL HYPERTENSION IN THE RAT
Author(s) -
SMITH G.W.,
SOMOVA LILIANA I.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb10403.x
Subject(s) - renal function , renal blood flow , kidney , medicine , endocrinology , effective renal plasma flow , prostaglandin , filtration fraction , renal circulation
1 Renal hypertension was produced in rats and the changes in renal function, renal venous prostaglandin E 2 and F 2α concentrations and secretion rates were studied at various times. 2 Renal plasma flow transiently fell in the ischaemic kidney 2 weeks after clamping, whilst that of the other kidney did not change. Glomerular filtration rate remained constant in both kidneys throughout the entire study. 3 Prostaglandins E 2 and F 2α concentrations rose in the venous plasma from the ischaemic kidney, but did not change in the other kidney and appeared to be inversely related to renal plasma flow. 4 Calculated secretion rate of both prostaglandins fell in the ischaemic kidney and did not change in the other kidney. 5 Clamping the second kidney, two weeks after the first, caused a further elevation in blood pressure, a fall in renal plasma flow and a fall in prostaglandin secretion rate in both kidneys. 6 The implications of these prostaglandin changes are discussed.