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ON THE DECREASE OF MYOCARDIAL OXYGEN CONSUMPTION INDUCED BY CHLORACYZINE
Author(s) -
KISIN I.E.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb10395.x
Subject(s) - oxygen , heart rate , cats , cardiology , medicine , anesthesia , blood pressure , blood flow , chemistry , organic chemistry
1 The effects of chloracyzine (2‐chloro‐10‐(3‐diethylaminopropionyl)‐phenothiazine hydrochloride; antianginal drug) on myocardial oxygen consumption were studied in open‐chest cats and cat isolated hearts using oximetry and polarography respectively. 2 It was found that chloracyzine produced a decrease in myocardial oxygen consumption accompanied by a reduction in coronary blood flow preceded by transient coronary dilatation. Chloracyzine produced an insignificant increase in arterial pressure; heart rate increased slightly in the open‐chest experiments but not in the isolated heart. 3 It is suggested that reduced oxygen uptake after chloracyzine is realized through improved efficiency in the use of oxygen.