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THE POSSIBLE INVOLVEMENT OF Na+ IONS IN CORTICOSTERONE‐INDUCED HYPERCONTRACTILITY IN THE RAT ANOCOCCYGEUS MUSCLE
Author(s) -
GIBSON A.,
POLLOCK D.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb10385.x
Subject(s) - contractility , corticosterone , ouabain , medicine , endocrinology , chemistry , muscle contraction , sodium , biology , hormone , organic chemistry
1 The possibility that corticosterone‐induced hypercontractility in the rat anococcygeus muscle might be due to an intramuscular redistribution of Na + was investigated. 2 The contractility of the isolated muscle to noradrenaline (NA) was directly dependent on the Na + concentration of the Krebs solution. 3 There was a linear relationship between the maximum contractile response of the muscle to NA and the Na + concentration of the Krebs solution. 4 Muscle contractility was also increased by the presence of ouabain (10 −4 m ) in the bathing medium. 5 Muscles from rats treated with corticosterone exhibited increases in both total and ouabain‐sensitive ATPase activity. 6 The relationship between corticosterone, Na + distribution, and muscle contractility is discussed.