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STEREOSPECIFIC ACTIONS OF 2,5‐DIMETHOXY‐4‐METHYLAMPHETAMINE (DOM) ON COLONIC TEMPERATURE IN THE RAT AT VARIOUS AMBIENT TEMPERATURES
Author(s) -
BEATON J.M.,
BENINGTON F.,
BRADLEY R.J.,
KUHLEMEIER K.V.,
MORIN R.D.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb10383.x
Subject(s) - methysergide , hypothermia , pimozide , tachyphylaxis , chemistry , pharmacology , anesthesia , stereospecificity , serotonin , receptor , medicine , endocrinology , haloperidol , biochemistry , dopamine , catalysis
1 The R(—) and S(+)‐isomers of 2,5‐dimethoxy‐4‐methylamphetamine (DOM) produce a dose‐dependent hypothermia in rats kept in the cold (6°C). 2 This hypothermia was linearly dependent upon ambient temperature and the R(—)‐isomer was considerably more potent than the S(+)‐isomer. 3 A statistically significant tachyphylaxis was observed when R(—)‐DOM was administered on two successive days. The response seven days after the second injection was similar to that on the first day of injection. 4 The hypothermia induced by R(—) and S(+)‐DOM was antagonized by methysergide but not by p‐ chlorophenylalanine (PCPA) or pimozide. Methysergide, PCPA or pimozide alone did not elicit hypothermia at the doses used. The results indicate that R(—) and S(+)‐DOM act at post‐synaptic 5‐hydroxytryptamine receptors.