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DUAL EFFECTS OF ASPIRIN IN GUINEA‐PIG LUNGS
Author(s) -
MIELENS Z. E.,
ROSENBERG F. J.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb10376.x
Subject(s) - bronchoconstriction , propranolol , atropine , aspirin , bronchospasm , guinea pig , pharmacology , in vivo , medicine , phenoxybenzamine , anesthesia , chemistry , asthma , biology , microbiology and biotechnology
1 Dual effects of aspirin were demonstrated in guinea‐pig lungs: (a) aspirin (3.3 mg/kg i.v.) antagonized bronchoconstriction induced by slow reacting substance of anaphylaxis (SRS‐A); (b) aspirin produced bronchoconstriction when injected in the presence of propranolol into guinea‐pigs in vivo at 330 mg/kg, or into guinea‐pig isolated lungs in vitro as a 4% solution (40 mg/ml). 2 The severity of bronchoconstriction following administration of aspirin was directly related to the degree of β‐adrenoceptor blockade and to the age of the guinea‐pigs. Aspirin‐induced bronchoconstriction was prevented in vivo and in vitro by atropine and it could be reversed in vivo by atropine. Aspirin‐induced bronchoconstriction was not inhibited by vagotomy or phenoxybenzamine. 3 These data suggest that the mechanism involved in aspirin‐induced bronchoconstriction may be local cholinergic stimulation and that reduced β‐adrenergic drive may be a predisposing factor.