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STUDIES ON THE MECHANISM OF ACTION OF AMANTADINE
Author(s) -
BROWN F.,
REDFERN P.H.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb08624.x
Subject(s) - amantadine , dopamine , dopaminergic , pharmacology , catecholamine , mechanism of action , chemistry , hydrochloride , medicine , in vitro , endocrinology , biology , biochemistry
1 The effect of amantadine hydrochloride on various aspects of catecholamine metabolism in the rat brain has been investigated. 2 Amantadine failed to have any significant effect on brain concentrations of dopamine or noradrenaline even when administered daily for 9 days. 3 Amantadine had no effect on the rate of decline of noradrenaline and dopamine concentrations after α‐methyl‐ p ‐tyrosine. 4 In vitro , amantadine inhibited dopamine uptake into synaptosomes only at high concentrations, and caused little release of dopamine from synaptosomes. 5 There is no evidence from these results to suggest that the anti‐Parkinsonian effect of amantadine is related to an action on dopaminergic mechanisms.