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EFFECT OF MORPHINE AND NALOXONE ON PRIMING‐INDUCED AUDIOGENIC SEIZURES IN BALB/c MICE
Author(s) -
CHEN C.S.,
GATES G.R.,
REYNOLDSON J.A.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb08618.x
Subject(s) - (+) naloxone , priming (agriculture) , morphine , medicine , pharmacology , endocrinology , anesthesia , chemistry , psychology , neuroscience , opioid , biology , receptor , botany , germination
1 Morphine (1–200 mg/kg, s.c.) reduced the incidence and prolonged the latency of priming‐induced audiogenic seizures in a dose‐dependent manner. 2 This effect was reversed by naloxone (1 and 2 mg/kg) although naloxone was itself inactive. 3 This priming‐induced seizure model may be useful in the study of tolerance and physical dependence.