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MAZINDOL ANOREXIA IS MEDIATED BY ACTIVATION OF DOPAMINERGIC MECHANISMS
Author(s) -
KRUK Z.L.,
ZARRINDAST M.R.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07713.x
Subject(s) - mazindol , dopaminergic , dopamine , pimozide , endocrinology , nomifensine , pharmacology , reserpine , medicine , chemistry , phenoxybenzamine , dopamine receptor , apomorphine , anorectic , propranolol , haloperidol , body weight
1 Anorexia in rats following injections of mazindol (0.1–8 mg/kg i.p.) could be antagonized by pretreatment with a dopamine receptor blocker (pimozide) but not by pretreatment with an α ‐ adrenoceptor blocker (phenoxybenzamine), a β‐adrenoceptor blocker ((‐)‐propranolol), or a 5‐hydroxytryptamine receptor blocker (methergoline). 2 In rats with a unilateral lesion in the substantia nigra made by stereotaxic injection of 6‐hydroxydopamine, mazindol caused a dose‐dependent turning towards the lesioned side, indicating an indirect mechanism of action. This effect could be antagonized by pretreatment with a dopamine receptor blocker. 3 In rats pretreated with reserpine and α‐methyl‐ p ‐tyrosine, mazindol did not have any motor stimulant action. 4 In vitro studies with synaptosomes prepared from rat brain, indicated that mazindol blocks uptake and causes release of dopamine. 5 It is concluded that the anorectic action of mazindol is mediated by a dopaminergic mechanism.