Premium
INFLUENCE OF DOPAMINE AND NORADRENALINE ON ISOLATED CEREBRAL ARTERIES OF THE DOG
Author(s) -
TODA N.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07700.x
Subject(s) - phenoxybenzamine , dopamine , medicine , methysergide , endocrinology , contraction (grammar) , propranolol , cerebral arteries , atropine , chemistry , aminophylline , adenosine , phentolamine , prostaglandin , serotonin , receptor
1 Effects of dopamine and noradrenaline were compared in helically‐cut strips of canine cerebral arteries. 2 Dopamine caused a greater maximal contraction than noradrenaline, although the ED 50 for noradrenaline was appreciably less. The contraction induced by these amines was reversed to a relaxation by treatment with phenoxybenzamine. 3 Relaxation induced by dopamine in phenoxybenzamine‐treated and prostaglandin‐contracted cerebral arteries was not influenced by 1 μ m propranolol, while relaxation induced by noradrenaline at low concentrations (2 μ m and 10 μ m ) was significantly attenuated. Neither aminophylline nor atropine affected the relaxant effect of dopamine. 4 A mechanism other than β‐adrenergic, cholinergic or adenosine‐related appears to be involved in the relaxation elicited by dopamine in cerebral arterial strips.