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EFFECTS OF l ‐TRYPTOPHAN AND l ‐METHIONINE ON ACTIVITY IN THE RAT
Author(s) -
TAYLOR M.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07699.x
Subject(s) - tryptophan , methionine , chemistry , essential amino acid , amino acid , pharmacology , biochemistry , biology
1 The effects of an intraperitoneal dose of 20 mg/kg L‐tryptophan and doses of 100 and 150 mg/kg of l ‐methionine were investigated on activity in the rat. 2 Activity was measured by a time sampling behaviour categorization procedure, and began 15 min after compound administration, lasting for a total of one hour. 3 Total active behaviour in the first half hour was reduced after 20 mg/kg tryptophan, 100 or 150 mg/kg methionine. Only 20 mg/kg tryptophan led to a significant reduction in active behaviour during the second half hour. 4 Administration of 100 mg/kg methionine plus 20 mg/kg tryptophan, and 150 mg/kg methionine plus 20 mg/kg tryptophan had no discernible effect on activity. 5 The results draw attention to the role of another amino acid in the modification of the behavioural effects of tryptophan.