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DETERMINATION OF HALOTHANE‐INDUCED SLEEPING TIME IN THE RAT: EFFECT OF PRIOR ADMINISTRATION OF CENTRALLY ACTIVE DRUGS
Author(s) -
TURNBULL M.J.,
WATKINS J.W.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07689.x
Subject(s) - halothane , meprobamate , anesthesia , medicine , pentobarbital , pharmacology , cross tolerance , morphine
1 A method is described for the determination of halothane‐induced sleeping time in the rat. 2 The sleeping time exhibited a diurnal variation which was due, at least in part, to a change in the sensitivity of the central nervous system (CNS) to the anaesthetic. 3 Tolerance to halothane did not develop in rats repeatedly exposed to the anaesthetic over a period of over 48 hours. 4 Repeated sleeping time determinations have been used to follow changes in the sensitivity of the CNS to the anaesthetic occurring with time. 5 A tolerance to halothane was induced by pretreatment of rats with doses of amylobarbitone, pentobarbitone or meprobamate sufficient to keep animals anaesthetized for approximately 12 hours. This tolerance was followed by a period of halothane‐hypersensitivity. 6 Halothane‐tolerant animals awakened with higher brain halothane concentrations and were also tolerant to intracerebroventricularly administered pentobarbitone. 7 Halothane‐hypersensitive rats awakened with lower brain halothane concentrations and were also hypersentive to intracerebroventricularly administered pentobarbitone. 8 The possibility that the induction of cross‐tolerance to halothane may be indicative of a drug's potential to produce dependence is discussed.