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FURTHER STUDIES ON THE MODE OF ACTION OF ISOPRENALINE ON GASTRIC SECRETION IN THE CONSCIOUS RAT
Author(s) -
LUNDELL L.,
SVENSSON S.E.,
NILSSON G.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07688.x
Subject(s) - isoprenaline , histamine , medicine , methacholine , endocrinology , pepsin , gastric acid , secretion , chemistry , pouch , gastrin , stimulation , biochemistry , anatomy , enzyme , lung , respiratory disease
1 The effect of isoprenaline on gastric secretion evoked by various means has been studied in conscious rats provided with Pavlov and Heidenhain pouches. 2 Interdigestive acid secretion in the Pavlov pouch was reduced by isoprenaline, whereas pepsin secretion was unaltered. 3 Central vagal stimulation effected by 2‐deoxy‐ d ‐glucose injection evoked a gastric secretory response that was substantially reduced by isoprenaline. 4 2‐Deoxy‐ d ‐glucose increased the mobilization of gastric mucosal histamine, an effect that was prevented by isoprenaline. 5 Isoprenaline infusion alone induced a slight increase in histamine mobilization and also a considerable elevation of immunoreactive serum gastrin concentration. 6 The secretory response to food in the Pavlov pouch was almost abolished by isoprenaline. 7 Although the acid response to histamine in the Heidenhain pouch was susceptible to isoprenaline inhibition, that to methacholine was not. 8 Pepsin secretion in the Heidenhain pouch preparation stimulated by histamine or methacholine seemed to be enhanced by isoprenaline.