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DECREASED PHENYLETHANOLAMINE‐ N ‐METHYLTRANSFERASE AND CATECHOL‐ O ‐METHYLTRANSFERASE ACTIVITY IN RABBIT ADRENAL GLANDS DURING PREGNANCY
Author(s) -
PARVEZ H.,
PARVEZ S.,
RAZABUKHARI A.,
YOUDIM M.B.H.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07682.x
Subject(s) - phenylethanolamine , endocrinology , medicine , catechol o methyl transferase , pregnancy , phenylethanolamine n methyltransferase , adrenal gland , epinephrine , methyltransferase , endocrine system , biology , chemistry , dopamine , hormone , biochemistry , methylation , allele , genetics , tyrosine hydroxylase , gene
1 Phenylethanolamine‐ N ‐methyltransferase (PNMT) activity in adrenal gland was lower than the control values at day 24 of rabbit pregnancy and fell throughout the gestational period. 2 Catechol‐ O ‐methyltransferase (COMT) activity during pregnancy and parturition followed a similar pattern to PNMT. 3 Adrenaline content of the adrenal gland declined significantly during the last few days of pregnancy but at parturition showed a tendency to return towards normal. 4 The biochemical mechanisms which result in a decline in PNMT and COMT activities and adrenaline concentration appear to be the consequence of modifications in endocrine gland secretion during pregnancy.