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EFFECTS OF SYMPATHOMIMETIC AMINES ON 45 Ca EFFLUX FROM LIVER SLICES
Author(s) -
HAYLETT D.G.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07668.x
Subject(s) - chemistry , efflux , sympathomimetics , endocrinology , pharmacology , medicine , biochemistry
The efflux of 45 Ca from slices of guinea‐pig and rabbit liver is greatly increased by α‐adrenoceptor agonists. Isoprenaline is much less effective. The effects of these agents on the efflux of 45 Ca mirror their actions on 42 K loss and suggest that the two may be related. Glucose release from both rabbit and guinea‐pig liver slices is increased to a similar extent by either α‐ or β‐receptor agonists. The possible relationship between Ca and K movements and the production of glucose is discussed.