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THE EFFECT OF ASPIRIN ON 5‐HYDROXYTRYPTAMINE UPTAKE AND RELEASE BY HUMAN PLATELETS
Author(s) -
RENDU F.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07665.x
Subject(s) - aspirin , platelet , chemistry , pharmacology , human blood , receptor , serotonin , 5 ht receptor , platelet aggregation , biophysics , endocrinology , biochemistry , medicine , biology , physiology
The influence of aspirin on 5‐hydroxytryptamine (5‐HT) uptake and storage by human blood platelets has been investigated. Uptake of 5‐HT was strongly inhibited. In 30 min aspirin released 50% of the 5‐HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5‐HT membrane receptor and the impairment of 5‐HT storage in the dense granules.