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THE DIFFERENT EFFECTS OF D‐600 (METHOXYVERAPAMIL) ON THE RELEASE OF ADRENAL CATECHOLAMINES INDUCED BY ACETYLCHOLINE, HIGH POTASSIUM OR SODIUM DEPRIVATION
Author(s) -
PINTO J.E.B.,
TRIFARÓ J.M.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07662.x
Subject(s) - acetylcholine , chemistry , catecholamine , physostigmine , potassium , endocrinology , sodium , medicine , calcium , depolarization , biology , organic chemistry
1 Bovine adrenal glands were perfused with Locke solution and catecholamine release was induced by acetylcholine, by a depolarizing concentration of potassium, or by omission of sodium from the perfusion fluid. 2 D‐600 (methoxyverapamil) at the concentration of 30 μ m produced a 23% inhibition of catecholamine release evoked by acetylcholine (0.1 m m ) in the presence of physostigmine (10 μ m ). 3 A concentration of D‐600 of 0.3 m m produced 86% and 85% inhibition in the output of catecholamines in response to acetylcholine and high potassium respectively. 4 D‐600 (0.3 m m ) failed to block the release of catecholamines evoked by sodium deprivation. 5 The results suggest the involvement of intracellular calcium in the exocytotic release of catecholamines induced by sodium omission.