Premium
EFFECTS OF SOME PURINE DERIVATIVES ON THE GUINEA‐PIG TRACHEA AND THEIR INTERACTION WITH DRUGS THAT BLOCK ADENOSINE UPTAKE
Author(s) -
COLEMAN R.A.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07655.x
Subject(s) - adenosine , guinea pig , purine , pharmacology , chemistry , block (permutation group theory) , medicine , biochemistry , enzyme , geometry , mathematics
1 Adenosine, adenosine 5′‐triphosphate (ATP), adenine, inosine and guanosine all caused concentration‐dependent relaxations of guinea‐pig tracheal smooth muscle in vitro . The relative potencies in descending order were: adenine ≥ guanosine > inosine ≥ adenosine ≥ ATP 2 Responses to the purine compounds were unaffected by propranolol (1 μg/ml). 3 The spasmolytic potencies of adenosine and ATP were greatly enhanced in the presence of the adenosine uptake blocking drugs dipyridamole, hexobendine or Dilazep, whereas responses to adenine were unaffected and those to inosine and guanosine were reduced. 4 The spasmolytic potencies of noradrenaline, aminophylline, prostaglandin E 2 and glyceryl trinitrate were unaffected by dipyridamole, hexobendine and Dilazep. 5 It is suggested that an adenosine uptake process may exist in the trachea of the guinea‐pig and that this process is inhibited by dipyridamole, hexobendine and Dilazep.