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HYPOTHERMIC ACTION OF CHLORPROMAZINE IN MONKEYS
Author(s) -
CHAI C.Y.,
FANN Y.D.,
LIN M.T.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07654.x
Subject(s) - medulla oblongata , chlorpromazine , hypothermia , anesthesia , medulla , chemistry , central nervous system , medicine , endocrinology , neuroscience , biology
1 In the conscious monkey ( Macaca cyclopis ) intravenous administration of chlorpromazine 0.1–8.0 mg/kg produced a fall of rectal temperature of 0.3 to 3.5°C after a latency of 3.5 to 10.8 minutes. The course of hypothermia lasted from 125 to 600 min or more. 2 Direct injection of chlorpromazine 100–800 μg into the lateral or fourth cerebral ventricle produced a similar fall of 0.3 to 2.0°C but with shorter latency (2 to 3.5 min) and with a duration of 94 to 375 minutes. 3 Two distinct structures in the brain stem, namely, the preoptic anterior hypothalamus (POAH) and medulla oblongata, responded to direct injection of chlorpromazine 200 μg. The sensitivity was slightly higher in the POAH than in the medulla. Structures in between were not sensitive. 4 The results suggest that chlorpromazine works principally through the central nervous system, i.e. the POAH and medulla oblongata, to mediate its hypothermic effect.