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THE EFFECTS OF PROSTAGLANDINS E 1 , E 2 AND F 2α ON THE CUTANEOUS VASCULATURE OF THE RAT
Author(s) -
CHAHL LORIS A.,
LADD R.J.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07645.x
Subject(s) - chemistry
1 The responses of the rat cutaneous vasculature to prostaglandins E 1 , E 2 and F 2α have been investigated by a photomicrographic technique. 2 Prostaglandin E 1 produced transient arterial constriction which was blocked by local pretreatment of preparations with compound 48/80 or methysergide. It was concluded that prostaglandin E 1 produced vasoconstriction by release of 5‐hydroxytryptamine (5‐HT) from mast cells. The magnitude of the vasoconstrictor response appeared to be subject to seasonal variation. 3 Prostaglandin F 2α produced arterial constriction of longer duration which was not blocked by compound 48/80, methysergide or phenoxybenzamine. 4 Preparations pretreated with prostaglandin F 2α were found to be more sensitive to the venous constrictor effect, and less sensitive to the arterial constrictor effect, of noradrenaline. 5 Prostaglandin E 2 produced arterial constriction which was usually partially blocked by compound 48/80 and methysergide and it was concluded that a major component of the vasoconstrictor response to prostaglandin E 2 was of the E 1 type but some component was of the F 2α type.