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BLOCKADE BY BURIMAMIDE OF THE RESTORATIVE EFFECT OF HISTAMINE IN TETRODOTOXIN‐TREATED HEART PREPARATIONS
Author(s) -
LEDDA F.,
MANTELLI LAURA,
MUGELLI A.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07474.x
Subject(s) - histamine , tetrodotoxin , antagonist , chemistry , blockade , pharmacology , medicine , receptor , biochemistry
1 In isolated heart preparations in which fast sodium channels were blocked by tetrodotoxin (2–4 × 10 −5 m ), excitability was restored by histamine (6 × 10 −6 M to 10 −5 m ). 2 This effect was antagonized by EDTA (2 × 10 −6 m ), D 600 compound (0.5 μg/ml) and the H 2 ‐receptor antagonist, burimamide (2 × 10 −4 m ).