Premium
NATURE OF HISTAMINE RECEPTORS IN THE EMETIC CHEMORECEPTOR TRIGGER ZONE
Author(s) -
BHARGAVA K.P.,
DIXIT K.S.,
PALIT G.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07469.x
Subject(s) - chemoreceptor , histamine , neuroscience , receptor , histamine receptor , histamine h2 receptor , chemistry , pharmacology , biology , medicine , biochemistry , antagonist
1 The protective effects of the intracerebroventricular (i.c.v.) administration of the H 1 ‐receptor antagonist, mepyramine and the H 2 ‐receptor antagonists, burimamide and metiamide on centrally induced histamine‐emesis were studied in unanaesthetized dogs. 2 The PD 50 values of intraventricular mepyramine, burimamide and metiamide against the 100% emetic dose of histamine (3.0 mg i.c.v.) were found to be approximately 200 μg, 20 μg and 20 μg respectively. 3 Although burimamide (i.c.v. or i.v.) afforded protection against histamine‐induced emesis, there was no protection against intravenous apomorphine‐or oral copper sulphate‐induced emesis. 4 The results suggest that both H 1 ‐ and H 2 ‐histamine receptors in the emetic chemoreceptor trigger zone of the area postrema are concerned in histamine‐induced emesis.