Premium
HISTAMINE H 2 ‐RECEPTORS IN THE HUMAN PERIPHERAL CIRCULATION
Author(s) -
CHIPMAN P.,
GLOVER W.E.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07463.x
Subject(s) - metiamide , mepyramine , histamine , receptor , brachial artery , histamine h2 receptor , histamine h1 receptor , stimulation , histamine receptor , endocrinology , medicine , forearm , peripheral , blood flow , chemistry , anesthesia , blood pressure , anatomy , antagonist
Histamine (10 μg/min for 3 min) infused into the brachial artery caused an increase in forearm blood flow which was reduced by mepyramine (25 mg). This effect was most marked in the first minute of the infusion. Metiamide (25 mg) had no effect on the dilatation during the infusion but caused a quicker return of flow to the resting level. The response was abolished when both drugs were given in combination. It is concluded that the response is initiated mainly by stimulation of H 1 ‐receptors and maintained by H 1 ‐ and H 2 ‐receptors; continued activity of H 2 ‐receptors may account for the slow return of flow to the pre‐infusional level.