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EFFECT OF SAS (A NEW 10‐N‐ACYLAMINOPHENOTHIAZINE) ON GASTRIC SECRETION AND ULCERATION IN RATS
Author(s) -
KUMAR A.,
SHARMA H.L.,
SHARMA V.N.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07462.x
Subject(s) - antispasmodic , pharmacology , parasympatholytic , gastric secretion , secretion , gastric acid , parasympatholytics , atropine , medicine , endocrinology , chemistry , muscarinic acetylcholine receptor , receptor
The antiulcer and antisecretory activity of 2‐chloro‐10‐[4′( N ‐β‐hydroxyethyl) piperazinyl‐1′] acetylphenothiazine (SAS) has been investigated. At 10 and 20 mg/kg (s.c.) the drug was found to possess potent antigastric secretory and antiulcer activity (both in shay and stress ulcers) and did not exhibit any peripheral parasympathetic blocking activity. The pronounced antispasmodic activity of SAS was nonspecific rather than a specific parasympatholytic effect.