Premium
THE RELATIONSHIP BETWEEN CALCIUM AND INCREASED SENSITIVITY OF RABBIT AORTAE FOUR HOURS AFTER RESERPINE
Author(s) -
CARRIER O.,
HESTER R.K.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07457.x
Subject(s) - reserpine , endocrinology , medicine , calcium , isoprenaline , chemistry , contraction (grammar) , acetylcholine , potassium , muscle contraction , biology , stimulation , organic chemistry
1 Four hours after reserpine, rabbit aortic strips were supersensitive to acetylcholine, isoprenaline and noradrenaline. The threshold concentration of the drugs necessary to induce a response was less and the maximum tension developed by the tissues was greater than in control strips. 2 Reserpine‐treatment potentiated the contractile responses to CaCl 2 . 3 Reserpine‐treatment resulted in an increase in calcium uptake and an increase in the slow component of 45 Ca 2+ efflux. 4 After resperine‐treatment, the rate of relaxation from a potassium‐induced contraction was decreased. 5 It is concluded that reserpine‐induced supersensitivity is related to an enhanced ability of the tissue to retain and utilize calcium.