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UPTAKE OF 5‐HYDROXYTRYPTAMINE IN DIFFERENT PARTS OF THE BRAIN OF THE RABBIT AFTER INTRAVENTRICULAR INJECTION
Author(s) -
DOW R.C.,
LASZLO I.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07456.x
Subject(s) - medulla oblongata , substantia nigra , pargyline , hypothalamus , cerebrospinal fluid , chemistry , serotonin , anatomy , biology , endocrinology , dopamine , central nervous system , neuroscience , biochemistry , receptor , dopaminergic
1 The uptake of 5‐hydroxytryptamine (5‐HT) was investigated in different areas of the rabbit brain (anterior hypothalamus, the raphe, the region of the substantia nigra, several cortical areas and the medulla oblongata) after intraventricular injection in pargyline pretreated animals by the formaldehyde‐induced histochemical fluorescence method. 2 The distribution of fluorescence showed that the uptake of 5‐HT, after circulation in the cerebrospinal fluid, caused a general increase in intensity of green yellow to yellow background fluorescence. There was an increased fluorescence in the nerve terminals, but no uptake occurred either in the cell bodies of neurones or in the glial cells.