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EFFECTS OF MAZINDOL, A NON‐PHENYLETHYLAMINE ANOREXIGENIC AGENT, ON BIOGENIC AMINE LEVELS AND TURNOVER RATE
Author(s) -
CARRUBA M.O.,
GROPPETTI A.,
MANTEGAZZA P.,
VICENTINI L.,
ZAMBOTTI F.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07454.x
Subject(s) - mazindol , pargyline , dopamine , chemistry , caudate nucleus , endocrinology , amphetamine , medicine , serotonin , biology , biochemistry , receptor
1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)‐amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5‐hydroxytryptamine (5‐HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by α‐methyl‐ p ‐tyrosine and decreased the conversion index of [ 3 H]‐tyrosine into brain NA. 4 Mazindol administration did not modify pargyline‐induced decline of 5‐hydroxyindoleacetic acid suggesting that 5‐HT turnover is not altered by this drug.