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THE DISTRIBUTION AND KINETICS OF SULPHACETAMIDE IN LEUKAEMIC MICE
Author(s) -
MARCHAND C.,
NADEAU D.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07453.x
Subject(s) - spleen , distribution (mathematics) , kinetics , pharmacokinetics , endocrinology , medicine , drug , absorption (acoustics) , chemistry , adipose tissue , brain tissue , muscle tissue , pharmacology , biology , mathematical analysis , physics , mathematics , quantum mechanics , acoustics
1 During the first 90 min following oral administration of sulphacetamide, there was a rapid decline in plasma drug concentration in control mice whereas a progressive increase in sulphacetamide concentration was observed in leukaemic mice. 2 Similar changes in the kinetics of sulphacetamide distribution were observed in the liver, spleen and muscle. 3 While the concentration of sulphacetamide remained quite constant in the brain and fat tissue of control mice, a progressive increase in drug concentration was observed in the brain and fat tissue of leukaemic mice. 4 Some of these changes in the kinetics of sulphacetamide tissue distribution are compatible with delay in gastrointestinal absorption of the drug and its accumulation in the ascitic fluid.