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HYPOTHALAMO‐PITUITARY ADRENOCORTICAL FUNCTION IN THE RAT AFTER TREATMENT WITH BETAMETHASONE
Author(s) -
BUCKINGHAM JULIA C.,
HODGES J.R.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07447.x
Subject(s) - adrenocorticotrophic hormone , endocrinology , medicine , betamethasone , adrenocorticotropic hormone , basal (medicine) , pituitary gland , corticosteroid , hormone , insulin
1 Hypothalamo‐pituitary‐adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawal. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached ‘supra‐normal’ levels. 4 The physiological significance and possible clinical relevance of the results are discussed.