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INFLAMMATORY EFFECTS OF PROSTAGLANDIN D 2 IN RAT AND HUMAN SKIN
Author(s) -
FLOWER R.J.,
HARVEY E.A.,
KINGSTON W.P.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb07446.x
Subject(s) - prostaglandin d2 , prostaglandin , histamine , extravasation , bradykinin , erythema , prostaglandin e2 , chemistry , vascular permeability , intradermal injection , endocrinology , pharmacology , human skin , prostaglandin e , edema , medicine , immunology , biology , receptor , genetics
1 Intradermal injection of prostaglandin (PG) D 1 and D 2 in the human forearm produced a long‐lasting dose‐related erythema. When compared with prostaglandin E 1 or E 2 the order of potency for erythema production was PGE 1 > PGE 2 > PGD 2 > PGD 1 . 2 In rat skin, prostaglandin D 2 but not D 1 caused an increase in vascular permeability as quantitated by the Evans blue method and the 125 I‐albumin extravasation technique. Prostaglandin E 2 was 3–5 times more potent than prostaglandin D 2 . 3 Prostaglandin D 2 (10 ng) potentiated the increase in vascular permeability in rat skin produced by histamine, but not that produced by bradykinin. 4 Prostaglandin D 2 (10, 20 and 50 ng) did not elicit oedema or hyperalgesia in the rat paw oedema test, but potentiated carrageenan‐induced oedema; hyperalgesia was potentiated by doses of 100 ng and above.