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EFFECT OF ATROPINE ON THE DECAY OF MINIATURE END‐PLATE CURRENTS AT THE FROG NEUROMUSCULAR JUNCTION
Author(s) -
FELTZ ANNE,
LARGE W.A.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb06965.x
Subject(s) - neuromuscular junction , atropine , anatomy , neuroscience , chemistry , biophysics , medicine , biology , anesthesia
1 The effect of atropine on the time constant of decay (τ) of miniature end‐plate currents was investigated. 2 The atropine‐induced shortening of τ was accompanied by a reduction in the voltage‐sensitivity of τ. 3 This effect of atropine was reversible and dose‐dependent, the voltage sensitivity being abolished with high concentrations of atropine (2.5 × 10 −5 m ).