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THE EFFECT OF EDROPHONIUM ON ERYTHROCYTE ACETYLCHOLINESTERASE AND NEUROMUSCULAR FUNCTION IN THE RAT
Author(s) -
BARBER H.E.,
CALVEY T.N.,
MUIR K.T.,
TAYLOR K.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb06963.x
Subject(s) - edrophonium , acetylcholinesterase , neuromuscular transmission , long term potentiation , chemistry , in vivo , pharmacology , endocrinology , anesthesia , medicine , neostigmine , biochemistry , biology , enzyme , receptor , microbiology and biotechnology
1 The relation between the concentration of edrophonium in plasma, inhibition of red cell acetylcholinesterase, and neuromuscular transmission was studied in the rat. 2 In both in vivo and in vitro conditions, red cell acetylcholinesterase activity was predictably related to the concentration of the quaternary amine. 3 After low doses of edrophonium (1.0 μmol/kg) there was a significant correlation between the monophasic potentiation of twitch tension and the plasma concentration of the drug. In contrast, with higher doses of edrophonium (4.0 or 10.0 μmol/kg) a biphasic potentiation of twitch tension was observed; this was only correlated with the plasma concentration of the drug during the secondary decline in neuromuscular facilitation. Subsequent recovery of normal neuromuscular transmission invariably occurred at a constant plasma concentration of edrophonium.