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PRESSOR EFFECTS OF TRYPTAMINE ANALOGUES
Author(s) -
BOSIN T.R.,
HIXSON E. JANE,
MAICKEL R.P.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb06954.x
Subject(s) - tryptamine , tryptamines , tyramine , chemistry , pharmacology , pressor response , medicine , endocrinology , biochemistry , blood pressure , heart rate
1 Methylation of tryptamine in the 1‐position had little effect on the potency of the drug as a pressor agent in the intact anaesthetized rat. 2 In contrast, substitution of a benzo[b]thiophene ring system for the indole ring decreased the pressor activity. 3 Pretreatment of the animals with reserpine reduced the pressor effect of tryptamine and its benzo[b]thiophene analogue while increasing the effect of the 1‐methylindole analogue. 4 Pretreatment with phenoxybenzamine reduced the pressor effect of all three compounds.