Premium
ANTIOXOTREMORINE ACTION OF PROPRANOLOL
Author(s) -
GANGULY D.K.
Publication year - 1976
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1976.tb06953.x
Subject(s) - oxotremorine , propranolol , antagonism , curare , chemistry , endocrinology , pharmacology , medicine , muscarinic acetylcholine receptor , biology , receptor
1 The influence of propranolol on the neuromuscular, tremor‐producing and muscarinic effects of oxotremorine was examined. 2 In the isolated rat phrenic nerve‐diaphragm preparation the neuromuscular blocking effect of oxotremorine was inhibited by propranolol in a dose‐dependent manner. 3 Propranolol intensified the paralytic effect of tubocurarine in the rat diaphragm and prevented antagonism of tubocurarine paralysis by tetraethylammonium. 4 Propranolol was devoid of any curare‐like effect in the isolated rectus abdominis muscle of the frog. 5 Vasodepressor responses to oxotremorine in rats and spasmogenic responses to oxotremorine in guinea‐pig ileum were not antagonized by propranolol. 6 A dose‐dependent antagonism of oxotremorine‐induced tremor in mice was observed after pretreatment with propranolol and it is suggested that this effect is due to an antagonism of a presynaptic effect of oxotremorine at skeletal neuromuscular junctions.