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THE EFFECTS OF HISTAMINE AND SOME HISTAMINE‐LIKE AGONISTS ON BLOOD PRESSURE IN THE CAT
Author(s) -
OWEN D.A.A.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07626.x
Subject(s) - histamine , receptor , blood pressure , chemistry , histamine h2 receptor , histamine receptor , pharmacology , medicine , endocrinology , cats , histamine h3 receptor , agonist , antagonist , biochemistry
1 The effects of histamine on blood pressure have been compared with the effects caused by four histamine‐like agonists in anaesthetized cats. 2 It has been confirmed that the depressor responses to histamine involve both H 1 ‐ and H 2 ‐receptors: depressor responses also follow the administration of selective H 1 ‐ and H 2 ‐receptor agonists. 3 2‐Methylhistamine, in doses up to 1 × 10 −7 mol/kg, lowers blood pressure by interaction with H 1 ‐receptors. Larger doses of 2‐methylhistamine also lower blood pressure but this may involve H 2 ‐receptors. 4 4‐Methylhistamine, in doses up to 1 × 10 −7 mol/kg, lowers blood pressure by interaction with H 2 ‐receptors. Larger doses of 4‐methylhistamine also lower blood pressure but this may involve H 1 ‐receptors. 5 2‐(2‐Aminoethyl)pyridine and 2‐(2‐aminoethyl)thiazole both lower blood pressure by interaction with H 1 ‐receptors only. 6 The potential value and limitations of these compounds as tools to investigate the cardiovascular effects of histamine are discussed.