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THE PENETRATION OF DAPSONE, RIFAMPICIN, ISONIAZID AND PYRAZINAMIDE INTO PERIPHERAL NERVES
Author(s) -
ALLEN B.W.,
ELLARD G.A.,
GAMMON PATRICIA T.,
KING R.C.,
McDOUGALL A.C.,
REES R.J.W.,
WEDDELL A.G.M.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07623.x
Subject(s) - dapsone , rifampicin , pyrazinamide , isoniazid , medicine , leprosy , tuberculosis , pharmacology , mycobacterium leprae , peripheral , drug , immunology , pathology
1 Dapsone, rifampicin, isoniazid and pyrazinamide were shown to penetrate readily into the sciatic nerves of the dog and sheep. 2 These findings suggest that the continued persistence of viable drug‐sensitive leprosy bacilli in the peripheral nerves of patients treated for long periods with either dapsone or rifampicin is not due to inadequate intraneural drug penetration.