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REDUCTION IN THE CHOLINESTERASE ACTIVITY OF THE RAT ANOCOCCYGEUS MUSCLE PRODUCED BY CORTICOSTERONE
Author(s) -
GIBSON A.,
POLLOCK D.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07612.x
Subject(s) - metyrapone , corticosterone , adrenalectomy , endocrinology , reserpine , medicine , chemistry , morphine , corticosteroid , cholinesterase , acetylcholine , hormone
1 Administration of corticosterone caused a 47% reduction in the cholinesterase (ChE) activity of homogenates of the rat anococcygeus muscle. 2 ChE activity was also reduced by morphine withdrawal and this effect was abolished by the corticosteroid synthesis inhibitor, metyrapone. 3 A single dose of reserpine reduced ChE activity in normal but not in adrenalectomized rats. 4 ChE activity was increased by adrenalectomy or by metyrapone treatment. 5 The mechanism of the corticosteroid‐induced reduction in ChE activity is discussed. 6 The reduction in ChE activity produced by corticosterone, morphine withdrawal, or a single dose of reserpine might explain the leftward shift of the dose‐% response curve to acetylcholine produced by these procedures in the isolated anococcygeus muscle of the rat.