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ANTI‐INFLAMMATORY ACTION OF GLUCAGON IN RATS
Author(s) -
LEME J. GARCIA,
MORATO M.,
SOUZA MARIA ZENILDE A.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07611.x
Subject(s) - glucagon , adrenal medulla , endocrinology , medicine , adrenalectomy , dextran , chemistry , insulin , biochemistry , catecholamine
1 Subcutaneous administration of glucagon (1 and 0.5 mg/kg) 30 min before the injection of carrageenin or dextran into the rat's paw reduced oedema and the local exudation of Evans blue previously given intravenously. 2 The effect persisted after removal of the adrenal medulla but not after adrenalectomy. 3 When glucagon (1 mg/kg, s.c.) was given daily after a local reaction to Freund's adjuvant injected into the paw had developed, a decrease in the reaction was observed up to 12 days. Blood sugar levels remained within the normal range. 4 Glucagon may exert an anti‐inflammatory effect through the release of adrenal corticosteroids and thus help modulate inflammatory reactions.