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ON THE ABILITY OF PROSTAGLANDIN E 1 AND ARACHIDONIC ACID TO MODULATE EXPERIMENTALLY INDUCED OEDEMA IN THE RAT PAW
Author(s) -
LEWIS A.J.,
NELSON D.J.,
SUGRUE M.F.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07609.x
Subject(s) - bradykinin , histamine , carrageenan , arachidonic acid , chemistry , prostaglandin e2 , cyproheptadine , prostaglandin e1 , pharmacology , long term potentiation , prostaglandin e , endocrinology , prostaglandin , medicine , biochemistry , serotonin , enzyme , receptor
1 Prostaglandins E 1 and E 2 but not prostaglandin F 2α , arachidonic acid or linolenic acid, produced slight oedema when injected into the rat hindpaw. 2 Prostaglandin E 1 potentiated hindpaw oedema produced by carrageenan, kaolin, bradykinin and trypsin but not that produced by 5‐hydroxytryptamine (5‐HT), histamine, dextran B or compound 48/80. Carrageenan‐ and bradykinin‐induced paw oedemas were also potentiated by prostaglandin E 2 . Arachidonic acid potentiated responses to carrageenan and kaolin but not responses to bradykinin, trypsin, 5‐HT, histamine, dextran B or compound 48/80. Linolenic acid did not potentiate hindpaw oedema induced by carrageenan. 3 Potentiation of carrageenan‐induced oedema by prostaglandin E 1 was not diminished by pretreatment with indomethacin, hydrocortisone or cyproheptadine. However, arachidonic acid potentiation of carrageenan oedema was reduced by pretreatment with non‐steroidal anti‐inflammatory drugs but not by anti‐inflammatory steroids or by paracetamol. 4 The enhancement of the response to carrageenan and kaolin by prostaglandins E 1 , E 2 and arachidonic acid is discussed in terms of kinin mediation.