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THE EFFECTS OF PROSTAGLANDINS E 1 , E 2 AND F 2α ON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE
Author(s) -
FENIUK W.,
LARGE B.J.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07608.x
Subject(s) - bradycardia , vagus nerve , medicine , chemistry , heart rate , blood pressure , stimulation
1 In anaesthetized mice prostaglandins E 1 and E 2 reduced the bradycardia caused by electrical stimulation of the sectioned peripheral vagus nerve; prostaglandin F 2α produced only a slight inhibition of the vagal response. 2 None of the prostaglandins studied affected acetylcholine‐induced bradycardia. 3 Prostaglandins modify para sympathetic nerve activity in vivo presumably by a pre‐synaptic action.